I'll throw in my two cents here, even though I've not ridden before (but getting closer...MSF in a week, and a bike soon afterwards (Suzuki M50, for anyone who cares

)...so take it with a grain of salt, or a shot of tequila, whichever...
I started looking at the V-Star 650's. Loved them. Saw the Suzuki M50, loved it more, but was concerned about the weight. I'm 5'11", 190 lbs.
I actually SAT on both bikes. Yes, the V-Stars have a GREAT, low weight feeling. The M50's weight is a little higher, but still not too bad. Sat on a Honda Sabre 1100. This thing's weight felt a bit higher.
Sat on a V-Star 1100, yes it was heavier, but still it was mainly "low", so it didn't feel bad at all.
As I've heard, and been told by my dad (who used to ride, but hasn't forever, but is excited for me to start) he said you can kill yourself on a 250...just be careful and know your (and the bike's) limitations.
Heck, I even went to the Victory dealer nearby and was talked into sitting on a Vegas. Man, if I had $15000 to blow, and a year or two of riding, I'd jump on that puppy. It, too, had GREAT weight distribution, but the thought of having a $15000 bike as my first left a bad taste in my mouth.
Anyway, what I guess I'm getting at is, you can die on a 250 as you can on a 1600 (cruisers...sport bikes are another story). Knowing your limitations, taking your time to learn the machine, and not being on a bike that makes you scared to death (you need to have a little bit of "fear" while riding to keep you aware, I've been told and agree with) are what's important.
I'll probably get the "smack-down" for saying this, but I don't see a problem with the 1100...as long as you are aware of it's capabilities and take your time.
*gets off soapbox that should be on, because hasn't riden yet*
