I rode for a couple years back in the early 90's when I was about 20, I had a CB650. A labrador retreiver darted out in front of me, I hit it, went over the handlebars and spent a week in the hospital with a ripped open knee , a broken ankle and numerous abrasions (the dog received some stitches and was released that day). I haven't ridden since. Of course back then I didn't know anything about MSF courses so I don't know if I could have avoided wrecking after hitting the dog or not. And of course I was wearing tennis shoes and jeans, so I may have been able to avoid the broken ankle and torn open knee if I had leathers and boots.
With the gas prices the way they are (as well as the entertainment value of bikes) I would like to give it another try. I am looking for a bike to commute to work, with great gas mileage. The cheaper the better. Used, old bikes are OK as long as they aren't beat up. My commute is 42 miles one way, mostly on regular 2 lane rural roads, with 8 miles on a 65mph highway, that then changes to 55mph for the last 7 miles.
I have no interest in speeding; you won't see me zipping around at 75mph on a bike. I know how bad it hurts. I am 6'1, 190-200 lbs with a 34" inseam.
I like the fuel economy of the 250's... a lot. Of course everyone around me says that I need something bigger, I'll get blown around and I'll grow out of it quickly. Well, right now my car is a Saturn SL1, not a Mustang. I'll be perfectly content to ride around at 55-60 mph, I just want it to do it well. And since my car gets around 35mpg, the bike needs to get great mileage to justify insurance, etc... a 42mpg bike isn't going to cut it.
At 100mpg, I would even consider a sportier looking scooter if my wife wouldn't divorce me over looking dorky on one, plus it's not fast enough for the highway.

Are there any fuel miser bikes that will carry me well and be comfortable enough for a drive like this?
Thanks...